SUMO unloads the Kap114 cab.

Sumoylation regulates Kap114-mediated nuclear transport.

The nuclear import receptor Kap114 carries transcription factors and other cargos across nuclear pores into the nucleus. Here we show that yeast Kap114 is modified by SUMO (small ubiquitin-related modifier) and that sumoylation is required for Kap114-mediated nuclear import. Among the four known SUMO-specific E3 ligases in yeast, Mms21 is the preferred E3 enzyme responsible for the covalent att...

I-34: Steroid Hormone Signalling at the FetomaternalInterface

Background: Progesterone is indispensable for differentiation of human endometrial stromal cells (HESCs) into decidual cells, a process that critically controls embryo implantation. However, HESCs also abundantly express androgen receptors (AR), yet the role of this member of the superfamily of ligand-dependent transcription factors in the decidual process remains poorly elucidated. Materials a...

Effect of respiratory exercises on the prevalence of atelectasis in patients undergoing coronary artery bypass surgery

Patients with coronary artery bypass (CAB) surgery are at risk of atelectasis. Use of respiratory exercises as effective approach has had controversy finding in CAB patients. This study aimed to determine the Effect of breathing exercises on the prevention of atelectasis in patients undergoing coronary artery bypass surgery. Materials and method: In this randomized clinical trial, 80 patients...

انعکاس مقالات محققان ایرانی در دو بانک اطلاعاتی کب (CAB) و اگریس (AGRIS)

Small ubiquitin-related modifiers in chains.

Post-translational modification of proteins by SUMOs (small ubiquitin-related modifiers) plays an important role in a wide variety of biological processes. The mammalian SUMO family includes three members, SUMO-1, SUMO-2 and SUMO-3. While target proteins are predominantly conjugated to monomeric SUMO, all three SUMO family members are able to multimerize in vitro. In cells, SUMOs have the poten...